Phthalic acid and derivatives
Medchemexpress LLC Guanosine, cyclic 3',5'-(hydrogen phosphate) (TBAOH) | 99.1% | 604.68 | 10 MG
Cyclic GMP (cGMP) TBAOH is an important second messenger and a major intracellular mediator of extracellular signals like nitric oxide (NO) and natriuretic peptides (NPs). Its effects are mediated through cGMP-dependent protein kinases (PKGs), cGMP-gated cation channels, and PDEs. Cyclic GMP can inhibit platelet adhesion and aggregation. cGAMP (Cyclic-GMP-AMP), a conjugate of Cyclic GMP and AMP, can induce IRF3 phosphorylation and nuclear translocation, enhancing antiviral immune responses.
- Important second messenger
- Intracellular mediator of extracellular signals (nitric oxide and natriuretic peptides)
- Inhibits both platelet adhesion and aggregation
- Can activate cGMP-mediated protein kinases
- Can activate cGMP-stimulated phosphodiesterases when acting synergistically with Isoprenaline, reversing cAMP-mediated enhancement or inhibiting cAMP-induced inward calcium current (ICa)
Medchemexpress LLC Cyclic GMP (TBAOH) | 99.1% | 604.68 | 1 ML
Cyclic GMP (cGMP) TBAOH is an important second messenger and a major intracellular mediator of extracellular signals such as nitric oxide (NO) and natriuretic peptides (NPs). Its effects occur through three main groups of cellular targets: cGMP-dependent protein kinases (PKGs), cGMP-gated cation channels, and PDEs. Cyclic GMP can inhibit both platelet adhesion and aggregation. cGAMP (Cyclic-GMP-AMP), a conjugate of Cyclic GMP and AMP, can induce IRF3 phosphorylation and nuclear translocation, enhancing antiviral immune responses.
- Important second messenger
- Major intracellular mediator of extracellular signals such as nitric oxide (NO) and natriuretic peptides (NPs)
- Affects cGMP-dependent protein kinases (PKGs), cGMP-gated cation channels, and PDEs
- Can inhibit both platelet adhesion and aggregation
- A conjugate can enhance antiviral immune responses
Medchemexpress LLC Cyclic GMP sodium | 40732-48-7 | 99.9% | 367.19 | 25 MG
Cyclic GMP (cGMP) sodium is an important second messenger and a major intracellular mediator of extracellular signals like nitric oxide (NO) and natriuretic peptides (NPs). Its effects are mediated through three main groups of cellular targets: cGMP-dependent protein kinases (PKGs), cGMP-gated cation channels, and phosphodiesterases (PDEs). It can inhibit both platelet adhesion and aggregation, and its conjugate, cGAMP, can enhance antiviral immune responses.
- Important second messenger.
- Major intracellular mediator of extracellular signals such as nitric oxide (NO) and natriuretic peptides (NPs).
- Mediates effects through cGMP-dependent protein kinases, cGMP-gated cation channels, and PDEs.
- Inhibits platelet adhesion and aggregation.
- Can enhance antiviral immune responses through its conjugate.
- Activates cGMP-stimulated phosphodiesterases synergistically with Isoprenaline.
Medchemexpress LLC Cyclic GMP | 7665-99-8 | 99.8% | 345.21 | 25 MG
Cyclic GMP (cGMP) is an important second messenger and a major intracellular mediator of extracellular signals such as nitric oxide (NO) and natriuretic peptides (NPs). Its effects are primarily through cGMP-dependent protein kinases (PKGs), cGMP-gated cation channels, and phosphodiesterases (PDEs). Cyclic GMP can also inhibit platelet adhesion and aggregation. cGAMP (Cyclic-GMP-AMP), a conjugate of Cyclic GMP and AMP, can induce IRF3 phosphorylation and nuclear translocation, thereby enhancing antiviral immune responses.
- Important second messenger.
- Major intracellular mediator of extracellular signals.
- Acts primarily through cGMP-dependent protein kinases, cGMP-gated cation channels, and phosphodiesterases.
- Can inhibit platelet adhesion and aggregation.
- Conjugate cGAMP can induce IRF3 phosphorylation and nuclear translocation.
- Enhances antiviral immune responses.
Medchemexpress LLC 8-CPT-Cyclic AMP sodium | 93882-12-3 | 99.7% | 493.79 | 10 MG
8-CPT-Cyclic AMP sodium is a selective activator of cyclic AMP-dependent protein kinase (PKA). It is also a potent inhibitor of the cyclic GMP-specific phosphodiesterase (PDE VA) with an IC50 of 0.9 μM. Additionally, 8-CPT-Cyclic AMP sodium inhibits PDE III and PDE IV with IC50 values of 5.5 μM and 6.6 μM, respectively, and is a potent Epac activator. It has been shown to delay TNF-α/CHX-induced and α-Fas-induced apoptosis in neutrophils.
- Selective activator of cyclic AMP-dependent protein kinase (PKA).
- Potent inhibitor of cyclic GMP-specific phosphodiesterase (PDE VA) with an IC50 of 0.9 μM.
- Inhibits PDE III and PDE IV with IC50 values of 5.5 μM and 6.6 μM.
- Potent Epac activator.
- Delays TNF-α/CHX-induced and α-Fas-induced apoptosis in neutrophils.
Medchemexpress LLC Dioctyl phthalate | 117-84-0 | 99.4% | 390.56 | 50 MG
Dioctyl phthalate (DNOP) is an active compound intended for research use only. This colorless to light yellow liquid has a high purity of 99.40% and a molecular weight of 390.56. It is crucial for various research applications.
- High purity (99.40%)
- Molecular weight of 390.56
- Appears as a colorless to light yellow liquid
- Suitable for research applications
- Store at room temperature, keep dry and cool
- Store in solvent at -80°C for 1 year or -20°C for 6 months
Medchemexpress LLC Cyclic AMP-13C5 (Cyclic adenosine monophosphate-13C5) | 2170095-23-3 | 97.5% | 1 MG
Cyclic AMP-13C5 is a deuterated cyclic AMP. This compound can be used as a tracer and as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS. Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Contains stable heavy isotopes.
TARGETMOL CHEMICALS INC BAY 61-3606 5MG
Also available in 1 mg 2 mg 10 mg 25 mg 50 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. BAY 61-3606 (Syk inhibitor IV) is a potent ATP-competitive reversible and highly selective inhibitor of Syk tyrosine kinase activity (Ki= 7.5 nM) exhibiting no inhibitory effect against Btk Fyn Itk Lyn and Src. purity: 98%
Apexbio Technology LLC Cyclic di-GMP(Synonyms: Cyclic diguanylate, c-di-GMP, diguanylate cyclase product), 500ug, CAS: 61093-23-0.
Cyclic di-GMP (CAS 61093-23-0) is an intracellular second messenger involved in diverse bacterial physiological processes including biofilm formation motility and pathogenicity It functions in mammalian cells as an agonist for Stimulator of Interferon Genes (STING) directly binding and activating it to induce innate immune responses Due to this mechanism cyclic di-GMP serves as a valuable tool for investigating STING-mediated immune modulation pathways and has research applications in cancer immunotherapy studies notably enhancing antitumor immunity in metastatic melanoma models
AdipoGen Pifithrin-alpha cyclic HBr
Chemical. CAS 511296-88-160477-34-1 free base. Formula C16H16N2S . HBr. MW 268.4 . 80.9. Stable analog of pifithrin-alpha. p53 inhibitor.
Frontier Specialty Chemicals 1G 3,5-BIS(METHOXYCARBONYL)PHE
3,5-Bis(methoxycarbonyl)phenylboronic acid pinacol ester; CAS: 944392-68-1; 1g
Apexbio Technology LLC Cyclic Pifithrin-α hydrobromide 511296-88-1 10mg
Cyclic Pifithrin- hydrobromide (CAS 511296-88-1) is a synthetic small molecule that functions as an inhibitor of the tumor suppressor protein p53 By blocking p53-dependent transcriptional activation of response genes it interferes with p53-mediated cellular processes such as apoptosis and cell cycle arrest In vitro Cyclic Pifithrin- hydrobromide inhibits p53-dependent apoptosis and DNA damage-induced growth arrest in various cell models without notable effects on p53-deficient cells In vivo it protects mice from the toxic side effects of genotoxic cancer therapies likely through suppression of p53-dependent pathways This compound is utilized in research investigating p53 biology cellular stress responses and modulation of chemotherapeutic toxicity
Frontier Specialty Chemicals 5G 3,5-BIS(METHOXYCARBONYL)PHE
3,5-Bis(methoxycarbonyl)phenylboronic acid pinacol ester; CAS: 944392-68-1; 5g